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- Sir William Osler
- William Osler
- Donny Osmond
- Marie Osmond
- Joel Osteen
- Richard N. Ostling
- Lee Harvey Oswald
- Marguerite Oswald
- Marina Oswald
- James Otis
- Don Ott
- Herbert Otto
- Howard Otway
- Ouida
- Fulton Oursler
- P. D. Ouspensky
- Frank Outlaw
- Thomas Overbury
- Mark Overby
- Patrick Overton
- Ovid
- Clive Owen
- John Owen
- Michael J. Owen
- Richard Owen
- Robert Owen
- Roderic Owen
- Wilfred Owen
- Bill Owens
- Buck Owens
- David Owens
- Jesse Owens
- John Oxenham
- Frank Oz
- Cynthia Ozick