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- Dave Storer
- Henry G. Stott
- Ruth Stout
- Harriet Beecher Stowe
- Lord William Stowell
- Lytton Strachey
- Igor Stravinski
- Igor Stravinsky
- Meryl Streep
- Barbra Streisand
- August Strindberg
- Arthur Stringer
- Anna Louise Strong
- William Strong
- Bjarne Stroustrup
- William Strunk Jr.
- Simeon Strunsky
- Janet Erskine Stuart
- Jesse Stuart
- Robert Stuberg
- Ruben Studdard
- Theodore Sturgeon
- Joseph Sugarman
- Louise Suggs
- Faith Sullivan
- Louis Henri Sullivan
- Arthur Hays Sulzberger
- Charles Sumner
- William Graham Sumner
- Sun-tzu
- Michael Sun
- Karen Sunde
- Robert Smith Surtees
- Bertha von Suttner
- Kathleen A. Sutton

- Han Suyin
- Shunryu Suzuki
- Claude Swanson
- Gloria Swanson
- Emanuel Swedenborg
- Ben Sweetland
- Laura Swenson
- Anne-Sophie Swetchine
- Madame Swetchine
- Jonathan Swift
- Charles Swindoll
- John Swinton
- Barry Switzer
- Herbert Bayard Swope
- Hermocrates of Syracuse
- Publilius Syrus
- Thomas Szasz
- Albert von Szent-Gyorgyi
- József Szombatfalvi